Maguire missed the midweek win over PSG in Paris but scored in the 4-1 thumping over Newcastle last weekend.
In his absence, Alex Tuanzebe excelled in a back three alongside Victor Lindelof and Luke Shaw, and Solskjaer could opt for a similar system, or else be forced to decide who partners his returning skipper.
Alex Telles looks likely to keep his place on the left after an impressive debut, while Edinson Cavani could be set to make his. With Anthony Martial suspended, Solskjaer will be relieved to have both the Uruguayan and Mason Greenwood available as attacking options, though both could start on the bench.
Fred and Scott McTominay started in midfield in Paris but have Paul Pogba and Donny van de Beek pushing for inclusions.
Man Utd predicted XI: De Gea, Maguire, Lindelof, Shaw, Telles, Wan-Bissaka, McTominay, Pogba, Fernandes, Greenwood, Rashford
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Source: Evening Standard Business News