Berlin: At least five people were killed on Wednesday when a bus headed from Berlin to Switzerland came off a highway in eastern Germany, authorities said.

The accident happened on the A9 highway near Leipzig at about 9.45am local time (7.45pm AEDT), closing the road in both directions.

The coach came to rest on its side on the A9, near Schkeuditz, Germany.Credit: AP

It wasn’t immediately clear why the bus, which was operated by Flixbus and en route from Berlin to Zurich, came off the road. Rescue helicopters and ambulances were at the scene.

Flixbus is a long-distance budget coach service that operates across mainland Europe.

Police spokesman Olaf Hoppe told n-tv television that there were “numerous injured and at least five dead.”

Flixbus said there were 53 passengers and two drivers on board, German news agency DPA reported.

The company said it was working closely with local authorities and rescue services to investigate the cause of the accident.

The A9 is a major north-south route that links Berlin with Munich.

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